Research

Research Cluster 1 - Health and Well Being

The Health and Wellbeing Cluster unit focuses its research on two main areas. 

The first main area of interest is to explore and unravel medicinal potential of compounds extracted from the vast collection of biodiversity Indonesia has to offer. This fundamental research will hopefully bring insights on novel Indonesian-based compounds for treating infectious disease and cancer. 

The second is to develop novel therapeutic applications and technology for improving the health and wellbeing of the Indonesian population. We aim to solve local and national health problems with innovative research in hope to elevate health and wellbeing services for the Indonesian population.

Research Focus

This research unit is dedicated to address local health problems with potentially global impact, such as the use of stem cells in tissue regeneration, isolation of components from the Indonesian Biodiversity with potential health enhancing properties, and infectious diseases such as malaria and tuberculosis. This research unit is also backed up by formulation and dosage form design to obtain effective drug delivery. We also pursue research on profiling of both cancer and infectious diseases agents in Indonesia in order to gain more insight and discover novel drugs based on Indonesia’s biodiversity.

This research unit is dedicated to applying our current understanding of fundamental biology, pharmacology, bioinformatics, and medicine to develop novel therapeutic interventions for various diseases. This would include interventions against cancer, infectious disease, genetic diseases, and physiological disease for personalized medicine as well as population health. Types of therapeutic interventions currently being developed include novel biopharmaceutical drugs, cosmetic treatments, herbal medicines, medical devices, and health-related applications for public health. The future aim of this research unit is to bring novel therapeutic intervention into clinical trials to improve the health and wellbeing of the Indonesia population.

Research Projects

Cluster 1 - Health and Well Being

Research Project 1

Characterization of T-cell immunity to SARS-CoV-2 in the South East Asian and European population


PI: Marsia Gustiananda, PhD
Team Member: Juliane Walz, MD, Jaturong Sewatanon, M.D., Ph.D., Dr. Sita Laksmi Andarini
External Collaborators: University Hospital Tuebingen, Faculty of Medicine Siriraj Hospital, Mahidol University, and Persahabatan Hospital

 

Research Project 2

Developing an Interaction Database on Drug-to-Drug Interactions that is Integrated with a Computerized Prescribing System in Hospitals 

PI: David Agustriawan, Ph.D.
Team Member: apt. Audrey A. Crystalia, M.Sc, Dr.rer.nat. Arli Aditya Parikesit, S.Si., M.Si.
External Collaborators: RS. Lira Medika

Research Project 3

The Use of Human Hair Keratin Matrix and Biocellulose from Kombucha Waste with the Active Substance of Tamanu oil (nyamplung oil) as a Dressing to Help Skin Regeneration in Diabetic Wounds 

PI: Pietradewi Hartrianti
Team Member: Solmaz Aslanzadeh, Leonny Hartiadi

Research Products

Cluster 1 - Health and Well Being

Research Product 1

Proses Pembuatan Matriks Komposit Pembalut Luka

Type: Product – Wound Healing – Patent
Year:
2020-2023
PIC:
Pietradewi Hartrianti, Apt., Ph.D.
Team Member (Faculty):
Katherine, S.T., Ph.D., Putu Virgina Partha Devanthi, S.Si., M.Si., Ph.D., Solmaz Aslanzadeh, B.Sc., M.Sc., Ph.D., Rizky Nurdiansyah, S.Si., M.Si., Wided Kouidhi, Ph.D.

Research Product 2

Komposisi dan Proses Pembuatan Sediaan dari Minyak Ekstrak Daun Gatal (Laportea decumana (Roxb.) Wedd) dan Penggunaannya 

Type: Product – Minyak Daun Gatal – Patent
Year: 
2017-2018
PIC:
Leonny Yulita Hartiadi, Apt., Ph.D
Team Member (Faculty): Pietradewi Hartrianti, Apt., Ph.D., Richard Sutejo, Ph.D., Dr. Dina Atrasina Satriawan, MNsci[Adv]

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Research Cluster 2 - Food Innovation and Nutrition

The Food Innovation and Nutrition Cluster unit is established for not only innovating the way food is grown, processed and distributed, but also aiming at the understanding the nutritive functions of food on health and well-being. 

Research activities in this unit focus on several key strategic areas, including but not limited to: Food Product Innovation, Functional Foods and Nutrigenomics, Food Quality Profiling and Nutrition and Lifestyle.

Research Focus

This research sub-unit is dedicated to investigate innovations in food ingredients, processing or packaging and apply them onto food products. One of the highlights is pursuing research on investigating the possible applications of native, natural, Indonesian ingredients onto foods. This research unit works hand-in-hand with the Food Quality Profiling sub-cluster, where various foods are investigated for relevant quality parameters to identify areas of improvement, and to investigate potential for innovations.

This research sub-unit is dedicated to explore the food components other than nutrients which provide human health benefits and to investigate gene–diet interactions to help food selection for optimal health or reduced risk of chronic diseases. One of the research focus is to investigate the antimicrobial and antioxidant properties of local fermented and non-fermented foods in Indonesia.

This research sub-unit is dedicated to profile relevant quality parameters associated with food products including: sensory evaluation, nutrition profiling, safety assessment, and shelf-life determination. The results found through the activities of this sub-cluster are used to support and start investigations of the other sub-clusters.

This research sub-unit is dedicated to investigate the association among nutrition, eating behavior, and lifestyle and their impacts on health and wellbeing. The research focus includes food choice and food consumption, dietary intake assessment, physical activity assessment, nutritional assessment, nutrient profiling, product development, and intervention strategies to promote health and wellbeing.

Research Projects

Cluster 2 - Food Innovation and Nutrition

Research Project 1

Development of Freeze-dried and Co-Crystallized Natural Red Carotenoids Pigments from Pandanus conoideus Lamk. for Food Applications

PI: Iwan Surjawan Ph.D.
Team Member: Katherine Ph.D. , M. Abdurrahman Mas M. Sc., Desak Putu Ariska Pradnya Dewi M.Sc.
Students Involvement: Samantha Tanardi, William, Irvandhi Stanly Winata, Leanne Marga Mulia, Maria Hajeng Paramita, Cindy Metta Clarissa

Research Project 2

Development of Brown Rice and Oyster Mushroom Based Food Products for Type 2 Diabetes Mellitus Patients

PI: Dr. Florensia Irena R. Napitupulu
Team Member: Siti Muslimatun, Ph.D., Widya Indriani, M.Sc., Rafsan Syabani Cholik, M.Sc.
External Collaborators: Prof. Dian Handayani SKM, M.Kes., PhD (Universitas Brawijaya)
Students Involvement: Michael Varrellino Arif, Nicholas Christopher, Dominic Yoel Thio, Marcellino Albert Pratignyo

Research Project 3

Effect of Temperature, Premix Concentration and Storage Time on Physicochemical Properties, Micronutrient Stability and Sensory Profile of Fortified Cookies

PI: Widya Indriani, S.T.P., M.Sc(MedSci)
Team Member: Rafsan Syabani Cholik, M.Sc.
Students Involvement: Chyntia Indrajaya, Fammela Sebastian, Natasha Clementina, Reyvan Vallian Sumarsono

Research Products

Cluster 2 - Food Innovation and Nutrition

Research Product 1

Proses Pembuatan dan Komposisi Serbuk Minyak Buah Merah sebagai Pewarna Alami Makanan dan Minuman 

Type: Product – Food Coloring Powder – Patent
Year: 
2020-2022
PIC: 
Iwan Surjawan, S.TP., M.Sc., Ph.D.
Team Member (Faculty): Desak Putu Ariska Pradnya Dewi, S.TP., M.Sc., Muhammad Abdurrahman Mas, B.Sc., M.Sc., Katherine, S.T., Ph.D.
Team Member (Alumni): Denis Arista Setiadi, Vania Amelia, Samantha Tanardi, William

Research Product 2

Metode Pembuatan Daging Nabati Bebas Gluten dengan Karakteristik Sensori yang Menyerupai Daging 

Type: Product – Daging Nabati – Patent
Year: 
2021
PIC: 
Natasya Khansa Childra
Team Member (Faculty): Muhammad Abdurrahman Mas, B.Sc., M.Sc., Iwan Surjawan, S.TP., M.Sc., Ph.D., Reni Mutiarani Saraswati, B.A.(Hons), M.B.Sys., Elita Jessamine Chandra, B.Com., M.M.
Team Member (Alumni): Erine Marcelina Gunawan, Lioni CarolOriana Namira Luqman, Sharon Quisheilla

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Research Cluster 3 -
Biotechnology for Sustainable Society

The Sustainable Bio-products and Services Cluster unit focuses on industrial biotechnology, biotechnology for food and health, and environmental biotechnology. We aim to harness biological resources, develop a sustainable bioprocess, and provide goods and services for society to minimize the negative impact of human activity on the environment and promote human health and wellbeing. 

We aim to explore Indonesia’s rich natural resources to explore and employ the capabilities of enzymes and microbes to develop functional foods, convert waste to products, and produce bioenergy and biomaterials, among others. Through our research program, we contribute to achieving the Sustainable Development Goals (SDGs).

Research Focus

This research sub-unit is dedicated to investigating the performance of alternative processing technologies with their respective fossil baseline. In part, the research focuses on exploring native organisms that can be used in commercial products and investigating the possibility of applying these biological sources for production processes with the potential of providing economic, environmental, and social benefits. In addition, the research aims to cover promising, recent, and novel research trends in the production of biomaterials, biochemicals, and biofuels that support long-term economic growth while minimizing the impact on society and the environment.

This research sub-unit is dedicated to exploring Indonesia’s rich natural resources to find and employ enzymes and microbes to produce food and healthcare products. The research primarily focuses on food fermentation technologies that utilize the growth and metabolic activity of microorganisms to transform food materials and food ingredients. Moreover, the research also studies the application and incorporation of beneficial microorganisms to produce functional food and supplements such as probiotics, prebiotics, and various healthcare products.

This research sub-unit is dedicated to addressing and tackling environmental problems caused by human activities using biological resources. The research mainly investigates bioremediation technologies and waste management technologies using plants and microbes for developing effective processes for eliminating various pollutants from wastewater, converting solid waste to value-added products and material.

Research Projects

Cluster 3 - Biotechnology for Sustainable Society

Research Project 1

Bacterial Cellulose production using Komagataeibacter intermedius isolated from fermented Kombucha

PI: Solmaz Aslanzadeh, Ph.D.
Team Member:  Putu Virgina Partha Devanthi, Ph.D., Katherine, Ph.D., Rizky Nurdiansyah, M.Sc.
External Collaborators: Prof. Mohammad J. Taherzadeh (University of Borås)
Students Involvement: Ferren Pratama, Karen Saphira Gotama, Arnaud Briot 

Research Project 2

Probiotic incorporation in bacterial cellulose produced by Komagataeibacter intermedius for application on wound healing

PI: Katherine, Ph.D.
Team Member: Pietradewi Hartrianti, Apt., Ph.D, Solmaz Aslanzadeh, Ph.D., Putu Virgina Partha Devanthi, Ph.D., Leonny Yulita Hartiadi, Ph.D., Apt
Students Involvement: Michael Putra Utama, Natasha Denisa

Research Project 3

Evaluation of Probiotic and Starter Culture Properties of Spray-dried Probiotics

PI: Putu Virgina Partha Devanthi, Ph.D.
Team Member: Katherine, Ph.D., Ihsan Tria Pramanda, M.S., Mario Donald Bani, S.P., M.Biotech (Adv.)
External Collaborators: Dr. Crystale Lim Siew Ying, Dr. Pui Liew Phing (UCSI, Malaysia)
Students Involvement: Jonathan, Gabriella Devina, Leon Martin, Matthew Chrisdianto, Laurentius Hardy Kurniawan, Devina Checylia Setiawan

Research Project 4

Organic Waste Valorization using Black Soldier Fly (Hermetia illucens) Larvae

PI: Solmaz Aslanzadeh, Ph.D.
Team Member: Ihsan Tria Pramanda, M.S., Putu Virgina Partha Devanthi, Ph.D.
External Collaborators: Ramadhani Eka Putra, Ph.D. (Institut Teknologi Bandung)
Students Involvement: Wafiqah Alsyurafa

Research Products

Cluster 3 - Biotechnology for Sustainable Society

Research Product 1

Revisiting Indonesia’s Fermented Food 

Type: Book – Copyright
Year:
2020-2021
PIC:
Ihsan Tria Pramanda, S.Si., M.Sc.
Team Member (Faculty):
Katherine, S.T., Ph.D., Putu Virgina Partha Devanthi, S.Si., M.Si., Ph.D., Solmaz Aslanzadeh, B.Sc., M.Sc., Ph.D

Research Product 2

Proses Fermentasi Kecap (Moromi) Rendah Garam Menggunakan Konsorsium Kultur Bakteri dan Ragi yang Diisolasi dari Proses Fermentasi Kecap Lokal Indonesia 

Type: Product – Low-salt Soy Sauce – Patent
Year: 
2018-2019
PIC: 
Putu Virgina Partha Devanthi, S.Si., M.Si., Ph.D. (PIC)
Team Member (Alumni): 
Sean Alexander Bastaman Limas

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Research Cluster 4 - Information Technology in Life Sciences

This research unit is to support all basic and applied research to better comprehend large datasets generated during the execution of the projects. Independently funded projects aim to map out the biodiversity of Indonesia, compute pharmacoinformatics data, curate medical databases, as well as implement comprehensive epidemiological studies. The main focus is to support and assist R&D at i3L and local industries.

Research Focus

This research unit focuses on how to understand data and molecular mechanisms of health and disease by combining structural data and modeling to predict new information and to rationalize drug design. Structural bioinformatics focuses on analysis and prediction of three-dimensional structure of biological macromolecules and elucidation of structure-function relationship as well as identification of important binding interactions.

This research unit focuses on research related to genome sequencing and structure of genes. The studies within this research topic also discuss all aspects connected to the cell and proteins. This fundamental research will hopefully bring insight into determining when and where genes are turned on or off in various types of cells and tissues, which may benefit in providing detailed information regarding gene activities and expression in cells.

Metabolomics research is utilized to discover, characterize and validate intra- and inter-cellular, dynamic molecular changes in a multitude of applications. It also focuses on studying metabolite diversity in organisms related to their biotic and abiotic factors, their function for interaction among organisms, and their benefit for human welfare. The focuses within this research unit are divided into plant metabolomics and nutri metabolomic.

Intelligent systems are technologically advanced machines that perceive and respond to the world around them. This research unit focuses on establishing systems and tools that can be utilized in biomedical and life science areas. Studies within this research unit are expected to provide knowledge and products that can be used on a daily basis to facilitate human beings effectively.

Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence, but instead involve a change in the way the genetic code is expressed. This research unit evaluates the gene activities in cancer cases and the effect of medication on the cancer structure. It is expected that the studies under this unit can bring insight in the development of cancer medication.

Biostatistics and Big Data have important roles in the process of analysis in the area of biology and life sciences. This research unit focuses on analysis, modeling and prediction processes. The studies in this research unit are expected to provide significant merits, especially in decision making

Evolution and diversity result from the interactions between organisms and their environments and the consequences of these interactions over long periods of time. This research unit focuses on the roles of biodiversity in maintaining healthy ecosystems and thereby sustaining ecosystem services to the ever-growing human population.

Research Projects

Cluster 4 - Information Technology in Life Sciences

Research Project 1

Study of 2 and 3-Dimensional Prediction of Breast Cancer Biomarkers from the Lincrna-Ror/Mir-145/Arf6 Expression Pathway


PI: Arli Aditya Parikesit
Team Member: Rizky Nurdiansyah, David Agustriawan
Students Involvement: Jeremias Ivan

Research Project 2

Transcriptomic Screening of Tilapia and Carp for Development of Rapid Diagnostic Kit Growth Markers

PI: Arli Aditya Parikesit
Team Member: Rizky Nurdiansyah, Agus Budiawan Naro Putra
External Collaborators: Research Institute for Fish Breeding, Subang, Indonesia (BRPI KKP)
Students Involvement: Stefanus Bernard

Research Project 3

Large-scale Domain Annotations of Human Breast Cancer-related Oncoprotein with Machine Learning-based Bioinformatics Tools

PI: Arli Aditya Parikesit
Team Member: David Agustriawan, Rizky Nurdiansyah

Research Project 4

Protein Domain Annotations of the SARS-CoV-2 Proteomics as a Blue-Print for Mapping the Features for Drug and Vaccine Designs

PI: Arli Aditya Parikesit
Team Member: Rizky Nurdiansyah

Research Project 5

Molecular Dynamics Simulation of the binding of anti-sense siRNA to the mRNA of the SARS-CoV-2 RdRp gene

PI: Arli Aditya Parikesit
Team Member: Rizky Nurdiansyah
External Collaborators: Genesia Foundation

Research Products

Cluster 4 - Information Technology in Life Sciences

Research Product 1

Linux and R Computational Protocol: Application of Statistics and Data Sciences in Cancer 

Type: Module – Copyright
Year: 
2021-2022
PIC:  
Dr.rer.nat. Arli Aditya Parikesit, S.Si., M.Si.
Team Member (Faculty): Assoc. Prof. David Agustriawan, S.Kom., M.Sc., Ph.D., Nanda Rizqia Pradana RatnasariI, S.Si., M.Stat.

Research Product 2

Pembuatan database interaksi antar obat yang terintegrasi dengan sistem peresepan terkomputerisasi pada rumah sakit untuk mengurangi kesalahan pengobatan dan meningkatkan efisiensi pelayanan resep

Type: Product – Database – Patent
Year:
2021
PIC: Assoc. Prof. David Agustriawan, S.Kom., M.Sc., Ph.D.
Team Member (Faculty):  Dr.rer.nat. Arli Aditya Parikesit, S.Si., M.Si., apt. Audrey Amira Crystalia, M.Sc., 
Team Member (Experts): Andreas Whisnu (Head of IT), Ike Veneqe (partner), Moch. Firmansyah (partner)

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Research Cluster 5 -
Valorization of Life-Sciences

Valorization in life sciences is part of the i3L School of Business that promotes the creation of economic value from the life sciences product focusing on the business point of view. Knowledge is better when it is applied to solve a problem and the components come from a holistic approach. The division has three clusters, such as (1) Business and Financial Management; (2) Digital Market and Corporate Governance; and (3) Innovation and Development Research.

Research Focus

Research on Business and Financial Management divided into two sub-clusters, which are:

1. Business Management

The research under sub-cluster Business Management involves the coordination and organization of business activities. It is a broad theme that can involve business and management aspects from each of the perspectives. 

2. Financial Management

The research under sub-cluster Financial Management involves planning, directing, and controlling the financial activities. It is also concerned with the practice of handling a company’s finances in a way that allows it to be successful and compliant with regulations.

Research on Digital Market and Financial Management divided into two sub-cluster, which are:

1. Digital Market

The research under the sub-cluster Digital Market involves the advertising delivered through digital channels to promote brands and connect potential customers using the internet and other forms of digital communication (e.g. search engines, website, email, mobile apps, text messaging, and web-based advertising).

2. Corporate Governance

The research under the sub-cluster Corporate Governance involves the system of rules, practices and processes by which a company is directed and controlled.

Research on Innovation and Development Research divided into two sub-cluster, such as: 

1. Business innovation

This sub-cluster introduces new processes, services or products to affect positive change in a business. It can include improving the existing methods or practices or even starting from scratch. The goal is to reinvigorate a business, creating new value and boosting growth and/or productivity.

2. Business development

Business development is the creation of long-term value for an organization from customer, markets, and relationships. It is also creating opportunities for that value to persist over the long-term, to keep the business running so that value can flow indefinitely.

Research Projects

Cluster 5 - Valorization of Life-Sciences

Research Project 1

Analisis Kelayakan Usaha Tamarillo Yoghurt (Yoghurt Terong Belanda) di Institut Bio Scientia International Indonesia

 

PI: Reni Mutiarani Saraswati
Team Member: Daniel Haryanto

Research Project 2

Studi Empiris Pengaruh Orientasi Strategis dan Klaster Inovasi Pada Kapabilitas Inovasi UKM TIK di Indonesia

 

PIReni Mutiarani Saraswati
Team Member: Fariz Hutama Putra Harjanto

Research Project 3

Pengaruh Motivasi Terhadap Pengalaman Pemilihan Makanan Sehat pada Konsumen Indonesia dan Swiss

 

PI: Tjong Budisantoso
Students InvolvementFariska Yosi Irianti

Research Project 4

Perbedaan Generasi X dan Y antara Pekerja Asing dan Lokal di Dunia Kerja

 

PI: Tjong Budisantoso
Students InvolvementFariska Yosi Irianti

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