Research Description:

Alzheimer’s Disease (AD) is a neurodegenerative disease impairing memory and causing mental and behavioral problems. By 2050, It is predicted that AD could affect 106.8 million people if there is no breakthrough in AD drug discovery. Novel drug for AD is urgently required as the current drugs targeting cholinesterase and N-Methyl-D-aspartate receptors fail to stop or prevent AD progression and have dose-dependent side effects. Previous studies suggest the promising effect of coriander leaves to improve memory and protect from AD. Coriander leaves contain quercetin, apigenin and linalool which are known to bind to potential novel targets of AD, namely γ-aminobutyric acid A receptors (GABAARs). In this study, coriander leaves will be extracted and evaluated in the AD mouse model. Memory function will be assessed using Y maze and novel object recognition and gene expression of neurogenesis markers, brain-derived neurotrophic factor (BDNF) and c-AMP response element-binding 1 (CREB1), will be monitored. The correlation of GABAARs with anti-alzheimer’s activity of the extract will also be investigated by administering GABAARs blocker. Further, the expression of GABAARs subunits and GABA level in the brain will be evaluated. The outcome of the research will give fundamental evidence for developing coriander as a herbal medicine product for AD.